Research Articles
*corresponding authors
M Minere, M Mortensen, V Dorovykh, G Warnes, D Nizetic, TG Smart* & SB Hannan* (2024). Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant. Brain, awae232
SB Hannan*, R Penzinger, G Mickute & TG Smart* (2023). CGP7930-An allosteric modulator of GABABRs, GABAARs and inwardly-rectifying potassium channels. Neuropharmacology 238, 109644
EF Halff, S Hannan, J Kwanthongdee, F Lesept, TG Smart & JT Kittler (2022). Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization. Science Signaling 15 (739), eabg2505
S Hannan*, K Au & TG Smart (2021). Inhibitory neurosteroid reverses the dendritic spine disorder caused by gain-of-function GABAAR epilepsy variants. bioRxiv, 2021.12. 08.471533
TW Church, P Tewatia, S Hannan, J Antunes, O Eriksson, TG Smart, JH Kotaleski & MG Gold (2021). AKAP79 enables calcineurin to directly suppress protein kinase A activity. Elife 10, e68164
S Hannan*, AHB Affandi, M Minere, C Jones, P Goh, G Warnes, B Popp, R Trollmann, D Nizetic & TG Smart (2020). Differential co-assembly of α1-GABAARs associated with epileptic encephalopathy. Journal of Neuroscience 40 (29), 5518-5530
S Hannan*, M Minere, J Harris, P Izquierdo, P Thomas, B Tench & TG Smart* (2020). GABAAR isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation. Neuropharmacology 169, 107540
S Hannan* & TG Smart* (2018). Cell surface expression of homomeric GABAA receptors depends on single residues in subunit transmembrane domains. Journal of Biological Chemistry 293 (35), 13427-13439
PS Miller, S Masiulis, T Malinauskas, A Kotecha, S Rao, S Chavali, L De Colibus, E Pardon, S Hannan, Z Sun, B Frenz, G Klesse, S Li, JM Diprose, CA Siebert, RM Esnouf, F DiMaio, SJ Tucker, TG Smart, J Steyaert, MM Babu, MSP Sansom, JT Huiskonen & AR Aricescu (2018). Heteromeric GABAA receptor structures in positively modulated active-states. bioRxiv 338343; doi: https://doi.org/10.1101/338343.
F McLeod, A Bossio, A Marzo, L Ciani, S Sibilla, S Hannan, GA Wilson, E Palomer, TG Smart, A Gibb & PC Salinas (2018). Wnt signaling mediates LTP-dependent spine plasticity and AMPAR localization through Frizzled-7 receptors. Cell Reports 23, 1060-1071
J Zapata, E Moretto, S Hannan, L Murru, A Longatti, D Mazza, L Benedetti, M Fossati, C Heise, L Ponzoni, P Valnegri, D Braida, M Sala, M Francolini, J Hildebrand, V Kalscheuer, F Fanelli, C Sala, B Bettler, S Bassani, TG Smart & M Passafaro. (2017). A novel interaction involving the epilepsy- and intellectual disability-linked protein Shrm4 and GABABRs shapes inhibitory neurotransmission in the brain. Nature Communications 8, 14536, DOI: 10.1038/ncomms14536
S Hannan, K Gerrow, A Triller & TG Smart. (2016). Phospho-dependent enrichment of mobile GABABRs at presynaptic terminals after NMDAR activation. Cell Reports 16, 1962-1973
A Murray, A Letourneau, C Canzonetta, E Stathaki, S Gimelli, F Sloan-Bena, R Abrehart, P Goh, S Lim, C Baldo, F Dagna-Bricarelli, S Hannan, M Mortensen, D Ballard, DS Court, N Fusaki, M Hasegawa, TG Smart, C Bishop, SE Antonarakis, J Groet & D Nizetic (2015). Isogenic induced pluripotent stem cell lines from an adult with mosaic Down syndrome model accelerated neuronal ageing and neurodegeneration. Stem Cells 33, 2077-84
S Hannan, M Mortensen & TG Smart (2015). Snake neurotoxin α-bungarotoxin is an antagonist at native GABAA receptors. Neuropharmacology 26, 28-40
M Mortensen, F Iqbal, AP Pandurangan, S Hannan, R Huckvale, M Topf, JR Baker & TG Smart (2014). Photo-antagonism of the GABAA receptor. Nature Communications 29, 4454. DOI: 10.1038/ncomms7829.
S Hannan, ME Wilkins & TG Smart (2012). Sushi Domains confer distinct trafficking profiles on GABAB receptors. Proceedings of National Academy of Sciences USA 109, 12171-12176.
S Hannan, ME Wilkins, E Dehghani-Tafti, P Thomas, SM Baddeley & TG Smart (2011). γ-Aminobutyric Acid Type B (GABAB) Receptor Internalization Is Regulated by the R2 Subunit. Journal of Biological Chemistry 286, 24324-24335.
S Hannan, D Ready, AS Jasni, M Rogers, J Pratten & AP Roberts (2010). Transfer of antibiotic resistance by transformation with eDNA within oral biofilms. FEMS Immunology & Medical Microbiology 59, 345–349.
Book Chapter
S Hannan, MW Wilkins, P Thomas & TG Smart (2012). Tracking the cell surface movement of GPCRs using α-bungarotoxin. Methods in Enzymology 521, 109–129
Saad Hannan 